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Abstract #1001

Co-transplantation of encapsulated human mesenchymal stem cells improves the viability of human islet xenografts in a mouse model of type I diabetes

Mangesh Kulkarni 1,2 , Dian Arifin 1,2 , and Jeff Bulte 1,2

1 Institute for Cell Engineering, the Johns Hopkins University School of Medicine, Baltimore, Maryland, United States, 2 Russell H. Morgan Department of Radiology and Radiological Science, Division of MR Research, Baltimore, Maryland, United States

Transplantation of microencapsulated islets circumvents the need for immunosuppression which is a requirement for the clinically used Edmonton protocol. We developed complementary strategies to improve transplant survival. Incorporation of perfluorocarbons within the capsules enabled in vivo monitoring using 19F MRI following subcutaneous implantation of human islets in a mouse model of type I diabetes mellitus. In this xenogeneic environment, encapsulated human islet viability was significantly improved following co-transplantation with encapsulated human MSCs.

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