Measuring Changes in Arterial and Venous Cerebral Blood Volume in Human Brain at 7T
Laurentius Huber 1 , Aneurin Kennerley 2 , Dimo Ivanov 3 , Claudine Gauthier 1 , Harald E. Mller 1 , and Robert Turner 1
Max Planck Institute for Human Cognitive and
Brain Sciences, Leipzig, Germany,
of Psychology, The University of Sheffield, United
and Neuroscience, Maastricht University, Netherlands
A CBV- and BOLD-sensitive multi-echo VASO sequence is
used to estimate arterial and venous CBV changes.
Separation between vascular compartments can be achieved
by modeling their T2* and oxygenation-dependent signal
contribution across TEs in MR images with and without
selective blood nulling. Spatiotemporal features of
arterial and venous CBV and their interaction with CBF
and BOLD responses is considered with respect to
position across the cortical ribbon, the post-stimulus
undershoot and sustained neural inhibition. It is
concluded that these features differ across time,
stimulus type and vessel type.
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