Diffusion MRI and in-vivo proton MR Spectroscopy Study of the Differentiation of Malignant Breast Tissue of Breast Cancer Patients and the Normal Breast tissue of Healthy Lactating Women Volunteers
Naranamangalam R Jagannathan 1 , Khushbu Agarwal 1 , Rani G Sah 1 , Uma Sharma 1 , Rajinder Parshad 2 , and Vurthaluru Seenu 2
Department of NMR & MRI Facility, All India
Institute of Medical Sciences, New Delhi, Delhi, India,
of Surgical Disciplines, All India Institute of Medical
Sciences, New Delhi, Delhi, India
Diffusion weighted imaging and in-vivo proton MRS in
lactating women volunteers (n=16) and in patients with
breast cancer (n=13) showed total choline peak in 16/16
malignant cases and in 11/13 lactating women volunteers.
Further, 11/13 of lactating women showed a lactose peak
at 3.8 ppm. tCho concentration was similar in both
groups while higher ADC was observed in lactating women.
Our study demonstrated that higher ADC value together
with the presence of a lactose peak may aid in the
differentiation of changes that occur in the breast
tissues due to normal physiological conditions as
compared with malignant transformations.
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