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Abstract #1048

A Simulation Study of the Flexible TWIST View Sharing Impact on the Breast DCE MRI

Yuan Le 1 , Marcel Dominik Nickel 2 , Randall Kroeker 2 , Christian Geppert 2 , Brian Dale 2 , Hal D. Kipfer 3 , and Chen Lin 1

1 Radiology and Imaging Science, Indiana University School of Medicine, Indianapolis, Indiana, United States, 2 Siemens Healthcare, North Carolina, United States, 3 Radiology and Imaging Science, Indiana University School of Medicine, Indiana, Indiana, United States

The acquisition of breast DCE-MRI using a flexible TWIST view sharing technique was simulated. A digital phantom was generated with three 5mm uniform spherical lesions of persistent, plateau and wash-out type of contrast uptake, and one 10 mm complex tumor with a mixture of all three types of enhancements. Our results show that with the typical spatial resolution in clinical breast DCE-MRI, TWIST view sharing parameters of pA=20% and pB=20% provides the lowest overall RMS error for all time points, while pA=50% and pB=50% produces image with minimum error at the peak contrast uptake.

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