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Abstract #1076

Aggressiveness Biomarker for Prostate Cancer in ADC-T2W MR Feature Space

Alpay zcan 1 , Baris Trkbey 2 , Peter Choyke 2 , and Seong K. Mun 1

1 Virginia Polytechnic Institute and State University, Arlington, VA, United States, 2 National Cancer Institute, Bethesda, MD, United States

Accurate localization of prostate cancer (PCa) is fundamental for effective surveillance and, guiding diagnostic and therapeutic interventions. However, an imaging biomarker is absent for this goal. Herein, the ADC-T2W MR feature space (MR-FS) is proposed for image guided PCa strategies. An interactive in-house software was implemented to incorporate objectively and directly physician's experience into the discovery process. The analysis of a 44 patient cohort revealed a specific region in MR-FS distinguishing aggressive from indolent PCa. By observing the pixels associated with the aggressive region, effective biopsy and therapy target localization and, active surveillance is achieved.

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