LOCAL VASCULAR INPUT FUNCTION FOR PHARMACOKINETIC MODELING OF PROSTATE CANCER
Hatef Mehrabian 1 , Masoom A. Haider 2 , and Anne L. Martel 1
Medical Biophysics, University of Toronto,
Toronto, Ontario, Canada,
Imaging, Sunnybrook Health Sciences Centre, Toronto,
A major component in multi-parametric MRI of tumors is
pharmacokinetic modeling of their DCE-MRI which provides
information about perfusion and vascular permeability.
Such analysis requires an AIF that is approximated
outside of the tissue and is a major source of error and
discrepancy among studies. Using a local vascular input
function (VIF) instead has the potential to improve PK
analysis. This paper investigates the effects of using
VIF (in 19 prostate DCE-MRI datasets) and shows more
consistent PK parameters are obtained for normal
peripheral zone tissue compared to using AIF and result
in better separation of tumor and normal tissues.
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