Abstract #1113
Monitoring therapeutic effect of a vascular disrupting agent: correlation between perfusion parameters derived from intravoxel incoherent motion diffusion-weighted imaging and dynamic contrast enhanced MRI
Ijin Joo 1 , Jeong Min Lee 1 , Joon Koo Han 1 , and Byung Ihn Choi 1
1
Seoul National University Hospital, Seoul,
Seoul, Korea
Dynamic contrast enhanced (DCE) MRI has been widely used
for noninvasive assessment of the change in tumor
perfusion. Recently, intravoxel incoherent motion (IVIM)
diffusion-weighted imaging (DWI) by using a
bi-exponential fitting of the DWI data from multiple
b-values has been reported to be useful for quantitative
measurement of tumor perfusion without requirement of
contrast medium. Our study using a rabbit liver tumor
model demonstrated significant correlation between
serially measured perfusion parameters derived from
IVIM-DWI and DCE-MRI in the vascular disrupting agent
(VDA)-treated group. Therefore, IVIM-DWI may be a useful
surrogate of DCE-MRI in the longitudinal monitoring
therapeutic effect of VDAs.
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