Evaluation of tumor oxygenation in response to an indole-based vascular disrupting agent using 19 F MRI
Heling Zhou 1 , Rami R Hallac 2 , Rebecca Denney 1 , Li Li 1 , Ramona Lopez 1 , Li Liu 1 , Edward E Graves 3 , Mary Lynn Trawick 4 , Kevin G Pinney 4 , and Ralph P Mason 1
Radiology, University of Texas Southwestern
Medical Center, Dallas, TX, United States,
Imaging and Modeling Center, Children's Medical Center,
Dallas, TX, United States,
Oncology and Radiology, Stanford University, CA, United
and Biochemistry, Baylor University, Waco, TX, United
Oxi8007, a novel vascular disrupting agent, showed rapid
and highly selective shutdown of tumor vasculature. In
this study we explored the onset of hypoxia with FREDOM,
oxygen mapping technique, to assess the pO
following the administration of Oxi8007 at two different
doses using an orthotopic breast cancer mouse model.
Both dose groups showed rapid decrease of pO
with a slower rate accompanying the lower dose. PO
revealed heterogeneous responses to the drug.
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