Adaptive Therapy: A Novel Cancer Treatment Regimen Using MRI.
Pedro M Enriquez-Navas 1 , Tuhin Das 1 , Yoonseok Kam 1 , Parastou Foruotan 1 , Gary Martinez 1 , Robert J Gillies 1 , and Robert A Gatenby 2
Cancer Imaging and Metabolism, Moffitt
Cancer Center, Tampa, Florida, United States,
Moffitt Cancer Center, Tampa, Florida, United States
Cancer is treated with the highest possible dose of
drug, depending on toxicity, to achieve the maximum drug
effect. However, this is a flawed approach because of
the evolutionary dynamics that depend on the variable
fitness across the tumor. Thus, the treatment scheduling
is suboptimal. Adaptive therapy (AT) is a novel cancer
therapy. The dose is dependent on the tumor status. The
key point is that AT has been demonstrated to promote
the growth of chemosensitive tumor cells at the expense
of chemoresistant ones. With the focus on translation,
we are applying MRI tools to fine tune AT in vivo.
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