Meeting Banner
Abstract #1137

Serial Imaging of Physiological and Metabolic Changes in Response to Radiotherapy with Tumor-Bearing Mice

Masayuki Matsuo 1 , Shingo Matsumoto 1 , Keita Saito 1 , Yoichi Takakusagi 1 , Douglas Morris 2 , Jeeva Munasinghe 2 , Nallathamby Devasahayam 1 , Sankaran Subramanian 1 , James Mitchell 1 , and Murali Krishna 1

1 Radiation Biology Branch, National Institues oh Health, North Bethesda, MaryLand, United States, 2 National Institute of Neurological Disorder and Stroke, National Institues oh Health, North Bethesda, MaryLand, United States

A non-invasive co-imaging system of pO2 and pyruvate metabolism was developed to visualize the correlation between tumor oxygen status and energy metabolism. SCCVII and HT29 were compared when the size of both tumors was similar. We investigated the effect of single 5 Gy irradiation on the relationship in HT29 tumors. SCCVII has significantly larger hypoxic sub-region (pO2 < 8 mmHg) than HT29. Lactate/pyruvate ratio in 0-8mmHg of 1 day after 5Gy irradiation of HT29 is higher than of non irradiation of HT29 that is explained by decreased perfusion, decreased tumor pO2, and increased extracellular acidification rate.

This abstract and the presentation materials are available to members only; a login is required.

Join Here