Abstract #1143
19 F MRI of Colitis-Associated Colon Cancer (CACC) in a Murine Model of Inflammatory Bowel Disease
Deepak K. Kadayakkara 1,2 , Soo Hyun Shin 3,4 , and Jeff W. M. Bulte 2,3
1
Dept. of Oncology, The Johns Hopkins School
of Medicine, Baltimore, Maryland, United States,
2
Dept.
of Radiology and Radiological Science, The Johns Hopkins
School of Medicine, Baltimore, Maryland, United States,
3
Cellular
Imaging Section, Institute for Cell Engineering, The
Johns Hopkins School of Medicine, Baltimore, Maryland,
United States,
4
Dept.
of Biomedical Engineering, The Johns Hopkins School of
Medicine, Baltimore, Maryland, United States
Invasive colonoscopy has showed that the severity of
colon inflammation correlates with the development of
colitis-associated colon cancer (CACC). We applied 19F
MRI to non-invasively image inflammation and
premalignant tumor formation. Mice were treated with
azoxymethane and dextran sodium sulfate to induce CACC.
The course of inflammation and tumor development was
determined with MRI following injection of
perfluorocarbons that are taken up by macrophages. 19F
signals were detected from the colon wall, with tumors
arising from the same anatomical sites. Thus, 19F MRI
appears useful to further characterize the relationship
between bowel inflammation and risk of CACC.
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