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Abstract #1148

Correlation between in vivo and ex vivo MRI of mouse mammary glands with regards to apparent diffusion coefficient and T2 values

Xiaobing Fan 1 , Kay Macleod 2 , Devkumar Mustafi 1 , Suzanne D Conzen 3 , Erica Markiewicz 1 , Marta Zamora 1 , Jim Vosicky 1 , Jeffrey Mueller 4 , and Gregory S Karczmar 1

1 Department of Radiology, The University of Chicago, Chicago, IL, United States, 2 Ben May Department for Cancer Research, The University of Chicago, Chicago, IL, United States, 3 Medicine, Hematology/Oncology, The University of Chicago, Chicago, Chicago, IL, United States, 4 Department of Pathology, The University of Chicago, Chicago, IL, United States

High resolution ex vivo imaging can improve understanding of cancer and guide evaluation of surgical specimens. The rationale for ex vivo MRI is strengthened if there is a strong correlation between ex vivo and in vivo images. Here we evaluate MRI at 9.4 Tesla of a mouse model (n = 7) of breast cancer. For ex vivo experiments, excised skin and glands were wrapped around a sponge to maintain the in vivo spatial configuration. There was a strong correlation (0.73 < r < 0.86, p < 0.0001) between the in vivo and ex vivo ADCs and T2s.

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