A Novel Gd-Sucrose Scaffold for Oral Administration in MR-colonography at 7 T
Parastou Foroutan 1 , Gary V Martinez 1 , Valerie E Moberg 1 , Suryakiran Navath 2 , Robert J Gillies 1 , Eugene A Mash 2 , and David L Morse 1
Cancer Imaging & Metabolism, H. Lee Moffitt
Cancer Center & Research Institute, Tampa, FL, United
of Chemistry and Biochemistry, University of Arizona,
Tucson, Arizona, United States
Colorectal cancer (CRC) is the second leading cause of
death in the United States and although CRC prognosis
relies on early-stage-disease detection, the standard
screening method, colonoscopy, suffers from patient
non-compliance. Magnetic resonance colonography (MR-C)
is a non-invasive approach that provides excellent soft
tissue contrast and 3D datasets without radiation
exposure. Herein, we present the development of targeted
contrast agents for pre-screening of CRC by 7 T MRI.
Specifically, a non-toxic Gd-DOTA sucrose based scaffold
for oral administration that can be conjugated to
targeting moieties specific for CRC was developed and
evaluated in phantoms as well as in vivo in xenografts.
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