Investigation of Relationship between Free-Water T1 and Age in Human Cortical Bone Employing Short-TE 1H-MRI at 1.5T
Atena Akbari 1,2 , Shahrokh Abbasi Rad 1,2 , Mohsen Shojaee Moghaddam 3 , and Hamidreza Saligheh Rad 1,2
Medical Physics and Biomedical Engineering
Department, Tehran University of Medical Sciences,
Tehran, Tehran, Iran,
MR Imaging and Spectroscopy Group, Research Center for
Molecular and Cellular Imaging, Tehran, Tehran, Iran,
Center, Payambaran Hospital, Tehran, Tehran, Iran
Larger pores in human cortical bone (>30 m) have
essential role in its mechanical competence, suggesting
to quantify such proton pools as a reliable measure of
cortical bone porosity and thus, cortical bone quality.
Signal from such pores can be reliably captured using
short echo time (STE) pulse sequence with echo-time in
range of 0.5-1msec. Furthermore, it is well-known that
cortical bone T1-relaxivity is a function of its
geometrical characteristics, suggesting
subject-dependent cortical bone free water increasing
with age. In this work, we investigated relationship
between STE-based cortical bone T1-values and age,
studies in a group of healthy volunteers at 1.5T.
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