Evaluation of the integration of silk fibroin ligament-like tissue into the bone after ACL reconstruction of the sheep model, using 7Tesla MR imaging.
Pavol Szomolanyi 1 , Andreas Teuschl 2,3 , Martin Brix 1,4 , Joachim Friske 1 , Vladimir Juras 1 , Xeni Deligianni 5 , Oliver Bieri 5 , Thomas Nau 6 , Heinz Redl 3,6 , and Siegfried Trattnig 1
Department of Biomedical Imaging and
Image-Guided Therapy, Medical University of Vienna, High
Field MR Centre, Vienna, Vienna, Austria,
of Vienna Competence Team Tissue Engineering
Bioreactors, University of Applied Sciences Technikum
Wien, Vienna, Austria,
Austrian Cluster for Tissue Regeneration, Vienna,
Department of Orthopaedics, Medical
University of Vienna, Vienna, Austria,
of Radiology, University of Basel Hospital, Division of
Radiological Physics, Basel, Switzerland,
Boltzmann Institute for clinical and experimental
Traumatology, Vienna, Austria
Most promising materials for ACL reconstruction are
based on silk fibroin as scaffold material.
Surprisingly, there is still a lack of knowledge on the
integration of silk fibroin scaffolds into bone. Thus,
the goal of this study was to evaluate the integration
of silk fibroin into the bone by using MRI UTE sequence.
MR analysis demonstrated that after 6 months the silk
scaffolds were surrounded by soft tissue that further
developed to the tight osteointegration. Our study show
that UTE is the technique of choice for MR imaging of
the very short T2* tissues.
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