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Abstract #1196

Quantitative MRI of Osteoarthritis for Multicenter Trials: Standardization between Different Centers and Manufacturers

Feliks Kogan 1 , Jarrett Rosenberg 1 , Emily J McWalter 1 , Daniel Park 2 , Stephen Matzat 1 , Kevin Prekins 2 , Catherine Tran 1 , Merideth Taylor 2 , Bragi Sveinsson 1 , Rex Newbould 2 , Uche Monu 1 , Haonan Wang 2 , Neal K Bangerter 2 , and Garry E Gold 1

1 Radiology, Stanford University, Stanford, CA, United States, 2 Electrical & Computer Engineering, Brigham Young University, Provo, UT, United States

In this study, we assessed the repeatability and reproducibility of quantitative MRI measurements of cartilage morphometry and tissue parameters intra-site and between sites and manufacturers. Quantitative measurements of tissue morphometry, T2, and sodium concentration were repeatable within a given site as determined by a high concordance correlation coefficient. Between sites with different manufacturers, correlation was high for morphologic imaging. Sodium concentration measurements showed a correctable bias while use of different acquisition sequences on different platforms for T2 measurements showed errors that are not easily correctable.

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