Disc Location Dependence of the Proteoglycan (PG) T2 value in Human Lumbar Intervertebral Disc
Anna M. WANG 1,2 , Iris Y. Zhou 1,2 , Adrian Tsang 1,2 , Ivy W. Han 1,2 , and Ed X. Wu 1,2
Laboratory of Biomedical Imaging and Signal
Processing, The University of Hong Kong, Hong Kong, Hong
of Electrical and Electronic Engineering, The University
of Hong Kong, Hong Kong, Hong Kong
This study explored the capability of proteoglycan (PG)
T2 value as a marker of the intervertebral disc
degeneration (IVDD). PG T2 and water T2 value, as well
as PG/water ratio were measured on 4 different disc
levels of lumbar spine. The PG T2 value showed a
slightly increasing trend from the upper disc level to
the lower disc level. The significant difference of PG
T2 value was found between disc L3-4 and disc L4-5 while
the water T2 and PG/water ratio showed no statistical
significant change between disc levels. Our result
suggests the increased PG T2 value could be the
reflection of disc degeneration taken place.
Demonstrated by this preliminary study, the PG T2
measurement on clinical scanner is highly feasible and
the PG T2 value might be a potential marker for the
early detection of disc degeneration.
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