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Abstract #1236

31P Wideband Inversion Transfer for Measuring ATP Synthesis Rates in Human Skeletal Muscle

Jimin Ren 1 , Baolian Yang 2 , A. Dean Sherry 1,3 , and Craig R. Malloy 1,4

1 Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas, United States, 2 Philips Healthcare, Ohio, United States, 3 University of Texas at Dallas, Richardson, Texas, United States, 4 VA North Texas Health Care System, Texas, United States

There has been a long-standing interest in measuring ATP synthesis rates in vivo. Conventional 31P saturation transfer requires prolonged saturation of gamaATP while inversion transfer by selective-inversion of gamaATP is less efficient, all due to rapid leaking of magnetization to other spins in the exchange network, especially phosphocreatine(PCr). Wideband inversion overcomes this problem by simultaneously inverting both PCr and ATP spins, allowing efficient transfer of magnetization to Pi. The advantage of wideband inversion is more evident at higher fields due to the increased PCr T1 value. The single 31P inversion pulse necessary for this technique is easy to implement.

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