Accurate measurement of intervertebral disc height loss demonstrates the threshold of major pathological changes during the course of degeneration
Joshua P. Jarman 1 , Dennis J. Maiman 2 , and L.Tugan Muftuler 3
Medical college of Wisconsin, Milwaukee, WI,
of Neurosurgery, Medical college of Wisconsin,
Milwaukee, WI, United States,
of Neurosurgery and Center for Imaging Research, Medical
College of Wisconsin, Milwaukee, WI, United States
The etiology of intervertebral Disc (IVD) degeneration
is still not completely understood. Degenerating discs
begin to lose proteoglycans, which is a water retaining
molecule. With the decrease in water, the discs lose
their ability to resist compression and torque.
Eventually the discs begin to lose height and structural
integrity. The goal of this study was to quantify
various pathological changes during the course of disc
degeneration using MRI biomarkers. We proposed a method
to quantify disc height loss with degeneration and
suggested that the decrease in IVD height would
correlate with other biomarkers of degeneration.
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