Abstract #1271
A novel method for quantifying inflammation of sacroiliitis in juvenile arthritis
Kanimozhi Vendhan 1 , David Atkinson 2 , Debajit Sen 3 , Corinne Fisher 3 , Yiannis Ioannou 4 , Paul Bassett 5 , and Margaret Hall-Craggs 6
1
UCLH, London, London, United Kingdom,
2
UCL,
London, United Kingdom,
3
UCLH,
London, United Kingdom,
4
Arthritis
Research UK Centre for Adolescent Rheumatology, UCL,
London, United Kingdom,
5
Statsconsultancy
Ltd, London, United Kingdom,
6
Imaging
Department, UCLH, London, United Kingdom
This was a retrospective case-control study to quantify
sacroiliitis in patients with juvenile arthritis by
using ADC maps. Along with conventional sequences, DWI
of the sacroiliac joints (SIJs) was performed at
multiple b values. A Matlab program was written to
create a profile of ADC values across the SIJs and a
reference sample in normal bone. This was done by
manually drawing a multiple linear regions of interest,
centered on the SIJ. There was a highly significant
difference between the ADC area scores of the cases and
controls. This novel technique for quantifying
sacroiliitis could potentially be used to monitor
response to therapy.
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