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Abstract #1351

Ladder-design volume coil with good uniformity and signal to noise for hyperpolarised 13 C investigations of animals on a 3T clinical system

Deborah K. Hill 1,2 , Craig Cummings 1 , Jessica K. R. Boult 1 , Matthew R. Orton 1 , Yuen-Li Chung 1 , Thomas R. Eykyn 1,3 , Martin O. Leach 1 , David J. Collins 1 , and Rafal Panek 1

1 CR-UK and EPSRC Cancer Imaging Centre, The Institute of Cancer Research and Royal Marsden NHS Trust, Sutton, Surrey, United Kingdom, 2 Department of Circulation and Medical Imaging, NTNU, Trondheim, Sr-Trndelag, Norway, 3 St Thomas Hospital, Kings College London, London, United Kingdom

Signal enhancement by Dynamic Nuclear Polarisation of 13 C makes it possible to conduct real-time measurements of low concentration metabolites in vivo . Implementation of preclinical work on clinical systems for DNP studies is attractive, but severely limited by surface coils when moving from subcutaneous to orthotopic and genetically modified models. We describe and characterise a custom-made 13 C volume ladder-design coil; the coil shows superior SNR and B 1 homogeneity in both phantom studies and in vivo in mice when compared to a typical surface coil.

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