GRE reference scan for robust reconstruction of high resolution slice and in-plane accelerated 2D GE EPI at 7T

High temporal, high spatial resolution 2D EPI requires acceleration along both the in-plane phase encode (e.g. GRAPPA) and slice directions (e.g. multiband, MB). For such acquisitions, image quality is particularly sensitive to motion during segmented multi-shot reference scans, which is lengthened by a factor of MB. We propose the GRE flash for in-plane unaliasing of high resolution slice accelerated 2D EPI. With this technique, motion during reference scan related artifacts and reconstruction noise are significantly reduces especially at higher spatial resolutions (<1.25mm isotropic). For 0.9mm data, we found SNR to improve by 40% over conventional segmented EPI reference scans.

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