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Abstract #1422

Imaging oculomotor subsystems in the cerebellum at 7 Tesla

Melissa A Batson 1,2 , Natalia Petridou 3 , Dennis WJ Klomp 3 , Maarten A Frens 2 , and Sebastian FW Neggers 1

1 Brain Center Rudolf Magnus, UMC Utrecht, Utrecht, Netherlands, 2 Neuroscience, Erasmus Medical Center, Rotterdam, Zuid Holland, Netherlands, 3 Imaging Division, UMC Utrecht, Utrecht, Netherlands

Using an innovative combination of high-density multi-unit surface coils, dual transmission, ROI shimming and 3D parallel imaging at 7T it is possible to clearly image the deep and complex structures and functions of the cerebellum during various motor tasks, including oculomotor tasks requiring eye tracking. Results demonstrate superior functional localisation within both oculomotor vermis and, when a cognitive component is present, in both CrusI and CrusII. In addition, BOLD signal strengths vary with the magnitude of difficulty of the task for both motor and cognitive components in a manner consistent with the changes in firing patterns observed in animal cerebellum.

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