The optimization of B1 insensitive T1 weighted MP2RAGE sequence at high field.
Wanyong Shin 1 , Sehong Oh 1 , Tobias Kober 2,3 , and Mark J Lowe 1
Radiology, Cleveland Clinic, Cleveland,
Ohio, United States,
Clinical Imaging Technology, Siemens Healthcare IM BM
PI, Lausanne, Switzerland,
cole Polytechnique Fdrale de Lausanne, Lausanne,
Large spatial B1 inhomogeneities are observed at
ultra-high magnetic field (=7T), which creates
non-uniform signal intensity across an image volume.
While MP2RAGE has shown the potential to minimize B1
variation, a long TR (>8s) is necessary to generate the
high signal to noise ratio and contrast to noise ratio
by providing the large dynamic contrast range. In this
study, we optimize fast MP2RAGE parameters to generate
T1 weighted contrast at 7T with 10% of image
non-uniformity in brain tissues. A healthy subject was
scanned with the optimized parameters according to
different TRs at 7T and brain segmentation results were
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