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Abstract #1423

The optimization of B1 insensitive T1 weighted MP2RAGE sequence at high field.

Wanyong Shin 1 , Sehong Oh 1 , Tobias Kober 2,3 , and Mark J Lowe 1

1 Radiology, Cleveland Clinic, Cleveland, Ohio, United States, 2 Advanced Clinical Imaging Technology, Siemens Healthcare IM BM PI, Lausanne, Switzerland, 3 CIBM-AIT, cole Polytechnique Fdrale de Lausanne, Lausanne, Switzerland

Large spatial B1 inhomogeneities are observed at ultra-high magnetic field (=7T), which creates non-uniform signal intensity across an image volume. While MP2RAGE has shown the potential to minimize B1 variation, a long TR (>8s) is necessary to generate the high signal to noise ratio and contrast to noise ratio by providing the large dynamic contrast range. In this study, we optimize fast MP2RAGE parameters to generate T1 weighted contrast at 7T with 10% of image non-uniformity in brain tissues. A healthy subject was scanned with the optimized parameters according to different TRs at 7T and brain segmentation results were compared.

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