Abstract #1520
Compressed Sensing Based J-Resolved Spectroscopic Imaging in Obstructive Sleep Apnea
Manoj Kumar Sarma 1 , Rajakumar Nagarajan 1 , Paul Michael Macey 2 , Ravi Aysola 3 , and M. Albert Thomas 1
1
Radiological Sciences, UCLA School of
Medicine, Los Angeles, CA, United States,
2
School
of Nursing, UCLA School of Medicine, Los angeles, CA,
United States,
3
Division
of Pulmonary and Critical Care Medicine, UCLA School of
Medicine, Los Angeles, CA, United States
Obstructive sleep apnea syndrome (OSAS) is a common
sleep disturbance affecting the adult population leading
to numerous health problems. Chronic intermittent
hypoxic episodes, hypercapnia and transient blood
pressure elevation in OSAS may damage neural structures
and induce cerebral metabolic changes. Even though many
structural imaging studies have shown brain tissue
changes in OSAS, only a limited number of MRS based
studies can be found so far. In this study, we
investigated neurochemical changes in multiple brain
regions of OSAS patients using compressed sensing (CS)
based Echo-planar J-resolved spectroscopic imaging (EP-JRESI)
and quantify the metabolites using prior knowledge
fitting (ProFit) algorithm.
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