Anatomically weighted 2 nd order Total Variation reconstruction of 23 Na MRI using 1 H prior information
Christine Gnahm 1 , Nicolas G.R. Behl 1 , Armin Biller 2 , Peter Bachert 1 , and Armin M. Nagel 1
Medical Physics in Radiology, German Cancer
Research Center (DKFZ), Heidelberg, Germany,
of Neuroradiology, University Hospital Heidelberg,
Na MRI is still hampered by low
signal-to-noise ratio (SNR) and long acquisition times.
We present an iterative reconstruction method using a
priori information from high-SNR high-resolution
MRI through anatomically weighted 2
Total Variation regularization (AnaWeTV). By anatomical
weighting, intensity variations in the
image are promoted at positions with high confidence of
tissue boundaries. In simulated brain images, it is
shown that the total sodium concentration in small
lesions that are known a priori can be determined more
precisely. Furthermore, we find a 2.2 fold SNR increase
over gridding in
MRI of a MS patient.
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