Multi-Direction Excitation for Magnetic Resonance Elastography to Increase the Fidelity of Mechanical Properties
Aaron T Anderson 1 , Curtis L Johnson 2 , Joseph L Holtrop 2,3 , Elijah EW Van Houten 4,5 , Matthew DJ McGarry 5 , Keith D Paulsen 5,6 , Bradley P Sutton 2,3 , and John G Georgiadis 1,2
Mechanical Science & Engineering, University
of Illinois at Urbana-Champaign, Urbana, IL, United
Institute for Advanced Science, University of Illinois
at Urbana-Champaign, Urbana, IL, United States,
University of Illinois at Urbana-Champaign, Urbana, IL,
de Gnie Mcanique, Universit de Sherbrooke, Sherbrooke,
School of Engineering, Dartmouth College, Hanover, NH,
Medical Center, Lebanon, NH, United States
Magnetic resonance elastography (MRE) has seen many
advances in shear wave drivers, imaging techniques, and
material property reconstruction but continues to have
issue with specificity of properties within anisotropic
microstructures due to the isotropic assumption.
Sections within the brain with highly ordered structure
behave very differently depending on the direction of
applied shear, longitudinal compared to transverse.
Adding multiple shaking directions, within the existing
isotropic framework, shows promise of increasing the
fidelity of all reconstructed material properties and
throughout the brain. The increase in fidelity will help
improve diagnosis of diseases affecting the
microstructure of the brain.
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