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Abstract #1698

MR elastography of MPTP-induced Parkinsons disease in the mouse

Ingolf Sack 1 , Barbara Steiner 2 , Charlotte Klein 2 , Elisabeth Hain 2 , Kerstin Riek 3 , Jing Guo 3 , and Jrgen Braun 4

1 Radiology, Charit-Universittsmedizin Berlin, Berlin, Berlin, Germany, 2 Neurology, Charit-Universittsmedizin Berlin, Berlin, Germany, 3 Radiology, Charit-Universittsmedizin Berlin, Berlin, Germany, 4 Medical Informatics, Charit-Universittsmedizin Berlin, Berlin, Germany

Magnetic resonance elastography (MRE) was applied to a murine model of neurotoxin-induced Parkinson's disease and compared to histological findings. For the first time, a significant increase of cerebral elasticity was observed in response to disease. We found an increase in the storage modulus of the brain at day 6 after treatment with the neurotoxin MPTP which parallels the proliferation of new neurons predominantly in the hippocampal region. The results provide insight into the crucial role of neurons for the constitution of the viscoelastic matrix and motivate further applications of MRE in patients as a new biomarker for neurodegenerative diseases.

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