Abstract #1706
Real-time MRI of Oropharyngeal Swallowing Function: Initial Clinical Results
Shuo Zhang 1 , Arno Olthoff 2 , Per-Ole Carstens 3 , and Jens Frahm 1
1
Biomedizinische NMR Forschungs GmbH,
Max-Planck-Institute for Biophysical Chemistry,
Goettingen, Lower Saxony, Germany,
2
Department
of Otorhinolaryngology, University Medical Center,
Goettingen, Lower Saxony, Germany,
3
Department
of Neurology, University Medical Center, Goettingen,
Lower Saxony, Germany
Previous studies of swallowing function using
conventional clinical methods suffer mainly from
invasiveness and limited visualization planes. Here, we
applied the recently introduced real-time MRI technique
based on undersampled radial FLASH and nonlinear
inversion, which provided consecutive T1-images of
swallowing actions with an in-plane resolution of 1.5 mm
and acquisition times of 41 ms (24 fps) almost free from
artifacts. Up to 12 distinct swallowing events with a
well-orchestrated temporal pattern could be
characterized. Preliminary clinical results with timing
quantification showed significant difference between
healthy subjects and patients with inclusion body
myositis, which promises a useful tool for disease
diagnosis.
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