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Abstract #1718

Quantitative 3D evaluation of white matter degeneration in rat spinal cord following Dorsal Column transection using frequency shift mapping

I-Wen Evan Chen 1 , Vanessa Wiggermann 1 , Jie Liu 2 , Wolfram Tetzlaff 2,3 , Piotr Kozlowski 1,4 , and Alexander Rauscher 1,4

1 MRI Research Center, Vancouver, B.C., Canada, 2 International Collaboration On Repair Discoveries, Vancouver, B.C., Canada, 3 Zoology, University of British Columbia, Vancouver, B.C., Canada, 4 Radiology, University of British Columbia, Vancouver, B.C., Canada

Recent studies of contrast in white and gray matter (WM/GM) of the central nervous system (CNS) have provided evidence for theories predicting phase (and frequency shift) dependence on tissue architecture, in the cellular and subcellular components of tissue [2-4]. Combining the well-defined (anisotropic) architecture of the rat spinal cord dorsal column (DC) transection model of axotomy, we study areas of neuronal damage consistent with (expected pathology) of Wallerian and retrograde degeneration. 3D frequency shift mapping of spinal cords bi-directional to the injury were generated from 3D multi-gradient echo (MGE) phase, and used to investigate progressive degeneration over several weeks

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