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Abstract #1732

Phase Sensitive Inversion Recovery in Post Mortem Multiple Sclerosis Spinal Cord: Shades of Grey and White

Amy McDowell 1 , Marc Miquel 2 , Maria Papachatzaki 1 , Daniele Carassiti 1 , and Klaus Schmierer 1

1 Neuroscience and Trauma, Blizard Institute, London, Greater London, United Kingdom, 2 Clinical Physics, Barts Health NHS Trust, London, Greater, United Kingdom

The usefulness of phase sensitive inversion recovery (PSIR) images in fixed post mortem multiple sclerosis (MS) spinal cord white matter (WM) and grey matter (GM) is examined. PSIR was optimised using T1 values acquired at 3T (inversion recovery method). The values obtained, and particularly the minor difference of T1 in WM and GM, suggest the assessment of the histological substrate of PSIR in post mortem spinal cord may not be feasible using fixed tissue. The use of unfixed samples should be explored, though access is limited

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