Exploring spatiotemporal dynamics of the cerebral blood flow of perinatal human brains with arterial spin labeling
Minhui Ouyang 1 , Peiying Liu 1 , Hanzhang Lu 1 , Lina Chalak 2 , Jonathan M Chia 3 , Andrea Wiethoff 1 , Nancy K Rollins 4 , and Hao Huang 1
Advanced Imaging Research Center, University
of Texas Southwestern Medical Center, Dallas, TX, United
of Pediatrics, University of Texas Southwestern Medical
Center, Dallas, TX, United States,
Healthcare, Cleveland, Ohio, United States,
Children's Medical Center, Dallas, Texas, United States
Cerebral blood flow (CBF) couples to neural activity and
can be used to characterize normal brain development.
The 3rd trimester is characterized with the rapid brain
growth. However, little is known about spatiotemporal
changes of CBF of the human brains during this period.
We hypothesized CBF dynamics is regionally heterogeneous
in the 3rd trimester. In this study, ASL was used for
quantifying regional CBF. We aim to acquire highly
reproducible and well validated ASL data of perinatal
brains in the 3rd trimester with sequence optimization
and explore the CBF dynamics during this period.
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