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Abstract #1743

What new do we learn with Myelin Water Fraction in infant white matter bundles in comparison with other MRI parameters?

Sofya Kulikova 1 , Lucie Hertz-Pannier 1 , Ghislaine Deahene-Lambertz 2 , Cyril Poupon 3 , and Jessica Dubois 2

1 UMR 663 Neurospin/UNIACT, INSERM-CEA, Gif-sur-Yvette, France, 2 UMR 992 Neurospin/UNICOG, INSERM-CEA, Gif-sur-Yvette, France, 3 Neurospin/UNIRS, CEA-Saclay, Gif-sur-Yvette, France

Conventional MRI/DTI parameters provide only indirect measures of the myelin content. Here we described the maturation of the white matter bundles in infants (3 - 21 weeks) using Myelin Water Fraction (a more direct myelin measure), and compared it with other parameters (quantitative qT1 and qT2 times, fractional anisotropy FA, mean , longitudinal λ║ and perpendicular λ┴ diffusivities). All parameters demonstrated asynchronous changes with age across different bundles. However, MWF was the most accurate in describing maturation asynchrony as it revealed more maturational relationships between the bundles and didnt violate the a priori known maturational relationships.

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