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Abstract #1766

In-vivo 3D Magnetic Resonance Volumetric Analysis of Fetal Cerebellum: From normal to pathology (unilateral cerebellar hypoplasia)

Martina Gianoni 1,2 , Marie Schaer 3 , Sbastien Tourbier 1,2 , Yvan Vial 4 , Maud Cagneaux 5 , Patric Hagmann 1 , Reto Meuli 1 , Laurent Guibaud 5 , and Meritxell Bach Cuadra 1,2

1 Radiology Department, University Hospital Center (CHUV) and University of Lausanne (UNIL), Lausanne, Vaud, Switzerland, 2 Center for Biomedical Imaging (CIBM), Lausanne, Vaud, Switzerland, 3 University of Geneva, Switzerland, 4 Department de Gyncologie-obsttrique, University Hospital Center (CHUV) and University of Lausanne (UNIL), Vaud, Switzerland, 5 Radiology Department, Hpital Femme, Mre et Enfant, Lyon, France

MRI is increasingly being used for the fetal central nervous system studies in vivo. Fast MR acquisition schemes in combination with advanced image processing reconstruction methods allow the quantitative studies of cerebellar volume of the fetus in-utero based on high resolution MRI. In this study we estimated the cerebellar volume of 9 healthy subjects coming from different sites. Their volumes match the previously reported results. We also study one case with unilateral cerebellar hypoplasia, showing that the pathological hemisphere is an outlier of the healthy hemispheric volumes regression over the gestational age.

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