Gradient Echo Plural Contrast Imaging in Studying Neonatal Brain Development: Preliminary Results
Jie Wen 1 , Jeffrey J. Neil 1,2 , Joseph Ackerman Jr. 1,2 , Jie Luo 3 , Terri E. Inder 2 , and Dmitriy A. Yablonskiy 1
Mallinckrodt Institute of Radiology,
Washington University in St. Louis, St. Louis, MO,
of Pediatrics Newborn Medicine, Washington University in
St. Louis, St. Louis, MO, United States,
Institute of Technology, MA, United States
Different methods have been used in the past to study
brain development. Gradient Echo Plural Contrast Imaging
(GEPCI) is a technique allowing generation of naturally
co-registered images with various contrasts within a
single MRI scan. The quantitative T2* and frequency maps
derived from GEPCI show stronger contrast and more
details compared with conventional clinical images.
Here, we demonstrate the feasibility of applying GEPCI
to evaluation of neonatal brain in health and disease.
Multi-contrast GEPCI images provide multi-perspective
means to explore neonatal brain development and injury
quantitatively. The quantitative R2* distribution
analysis shows substantial differences between term and
preterm borne neonates.
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