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Abstract #1776

Regional cerebral blood volume (rCBV) bias voxel-based morphometry (VBM) in an animal study

Dirk Ernst Cleppien 1 , Lei Zheng 2 , Claudia Falfan-Melgoza 1 , Barbara Vollmayr 3,4 , Wolfgang Weber-Fahr 1 , and Alexander Sartorius 3

1 RG Translational Imaging, Department of NeuroImaging, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany, 2 Experimental Radiation Oncology, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany, 3 Department of Psychatry and Pschotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany, 4 RG Animal Models in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany

Neuroplastic effects of the brain are able to be visualized by magnetic resonance imaging techniques like voxel-based morphometry (VBM). One possible drawback could be sensitivity to reversible changes of the brain structure like regional cerebral blood volume (rCBV) changes without any underlying effect on neuroplasticity. Therefore, our hypothesis was that rCBV partially explains the variance of VBM changes. For this, we compared the VBM results analysed in two different ways, one with rCBV as a covariate per voxel and one without, in order to state the influence of rCBV on GM probability maps.

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