Abstract #1806
Metabolite concentration changes in the human auditory cortex using functional Magnetic Resonance Spectroscopy (fMRS) at 7 Tesla
Benoit Schaller 1 , Lijing Xin 2 , and Rolf Gruetter 1
1
Laboratory of Functional and Metabolic
Imaging, Ecole Polytechnique Fdrale de Lausanne,
Lausanne, Vaud, Switzerland,
2
Department
of Radiology, University of Lausanne, Lausanne, Vaud,
Switzerland
Functional MRS investigates metabolite changes during
neuronal activation by continuously acquiring MR spectra
during a functional task. Recent fMRS studies performed
at 7 T reported similar metabolite changes, in
particular a lactate increase around 10-20% during
visual and motor activation. Thus, it is of interest to
further characterize the relationship between neuronal
activation and energy metabolism, in other brain areas,
such as the auditory cortex in the human brain
investigated here for the first time. Statistically
significant increases of Lac by 114% (p<0.02, n=7) and
of Glu by 21% (p<0.007, n=7) were found. We suggest
that Glu and Lac changes may be a general manifestation
of neuronal activation.
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