Abstract #1809
Blood volume functional MRI of the mouse whole brain
Linlin Cong 1 , Eric R. Muir 1 , William E. Rogers 1 , Bryan H. De La Garza 1 , KC Biju 2 , Robert A. Clark 3 , and Timothy Q. Duong 1
1
Research Imaging Institute, University Texas
Health Science Center at San Antonio, San Antonio,
Texas, United States,
2
Department
of Medicine, University Texas Health Science Center at
San Antonio, San Antonio, Texas, United States,
3
Insititute
for integration of Medicine & science and south Texas
Veterans Health Care System, San Antonio, Texas, United
States
Olfaction is one of the most important sensory systems,
particularly for rodents. Investigation of the olfactory
network from olfactory bulb to the whole brain opens a
unique window for us to better understand numerous brain
functions. To our knowledge, no previous studies on the
whole brain circuit activation in rodent with odor
stimulation have been reported. A novel method is
necessary for investigation of the pathway of olfactory
function. In this study, fMRI responses of the mouse
whole brain to odor stimulation was achieved by using
blood-volume weighted magnetic iron oxide nanoparticles
(MION) to achieve high fMRI sensitivity.
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