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Abstract #1817

Differential involvement of cortical and cerebellar areas using dominant and non dominant hands

Adnan Alahmadi 1,2 , Rebecca Samson 1 , David Gasston 3 , Egidio D'Angelo 4,5 , Ahmed Toosy 1,6 , and Claudia A.M. Wheeler-Kingshott 1

1 NMR Research Unit, Department of Neuroinflammation, Queen Square MS Centre, UCL Institute of Neurology, London, United Kingdom, 2 Department of Diagnostic Radiology, Faculty of Applied Medical Science, KAU, Jeddah, Saudi Arabia, 3 Department of Neuroimaging, Institute of Psychiatry, King's College London, London, United Kingdom, 4 Department of Brain and Behavioral Sciences, Neurophysiology Unit, University of Pavia, Pavia, Italy, 5 Brain Connectivity Center, IRCCS C.Mondino, Pavia, Italy, 6 NMR Research Unit, Department of Brain Repair and Rehabilitation, Queen Square MS Centre, UCL Institute of Neurology, London, United Kingdom

We investigated common and specific brain activations in contra and ipsi-lateral (CL and IL) hemispheres using a complex motor fMRI task with variable grip force performed with dominant and non-dominant hands (DH and NDH) in right handed healthy subjects. We showed there are: 1) increased activations in more areas at the highest force when performing the task using the NDH. 2) More activations in the right hemisphere irrespective of the hand or force level. 3) Common areas in CL and IL hemispheres at specific force levels such as SMA. 4) Consistent bilateral cerebellum involvement when performing the task using NDH

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