Abstract #1827
BOLD Evoked Response during Hyperbaric conditions
Damon P Cardenas 1,2 , Eric Muir 1,2 , Shiliang huang 2 , and Timothy Duong 1,2
1
Radiology, University of Texas Health
Science Center at San Antonio, San Antonio, Texas,
United States,
2
MRI,
Research Imaging Institute, San Antonio, Texas, United
States
There are substantial interests in the effects of basal
oxygen saturation on BOLD fMRI responses. We evaluated
forepaw-evoked BOLD responses in rats under i)
normobaric air, ii) normobaric oxygen, iii) 3
atmospheres hyperbaric air, and iv) 3 atmospheres
hyperbaric oxygen (HBO). Robust and strong BOLD
responses were detected under HBO similar to normobaric
air condition, suggesting that there is room to increase
total hemoglobin saturation or that other signal
mechnisms are involved during HBO.
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