Improvements to Time-SLIP Imaging of CSF Flow
Matthew Borzage 1,2 , John Grimm 3 , Tom Perkins 4 , Jon Chia 4 , Gordon McComb 5 , and Stefan Blml 3,6
Children's Hospital Los Angeles, Los
Angeles, CA, United States,
Schulte Research Institute, Santa Barbara, CA, United
Children's Hospital Los Angeles, CA, United States,
Healthcare, OH, United States,
Hospital Los Angeles, CA, United States,
Schulte Research Institute, CA, United States
The timeSLIP modality has potential to assist the
management of hydrocephalus and related disorders.
However, in practice, the variable delay times between
tagging and readout result in different levels of
background suppression and renders the clinical
interpretation sometimes difficult. We tested a new
approach, where background signal is constant and flow
is visualized with the MR readout occurring at different
cardiac cycle time points. Preliminary studies of 17
patients including cases with no CSF flow, or restored
CSF flow resulted in imaging results as expected, and a
positive change of patient management.
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