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Abstract #1837

Altered functional connectivity of rhesus brain during increasing levels of sevoflurane: a resting-state fMRI study on 3T

Yuan Xiao 1 , Peilin Lv 2 , Su Lui 1 , Min Wu 1 , Yuqing Wang 3 , Bin Liu 2 , and Qiyong Gong 1

1 Radiology, Huaxi MR Research Center, Chengdu, Sichuan, China, 2 Anesthesiology, West China Hospital of Sichuan University, Chengdu, Sichuan, China, 3 Radiology, West China Hospital of Sichuan University, Chengdu, Sichuan, China

In spite of many years research, the exact mechanism of how anesthetics modulate the cerebral function is still unknown. One possible mechanism is that anesthetics could influence the synchrony of neuronal networks as reflected by studies on rats, though the results were controversial 1, 2. However, it is still unclear whether such effects would be observed in rhesus monkeys which are closer to human than rats. Moreover, most previous animal studies were performed at a single anesthetic dose rather than graded levels of anesthesia; the latter one can potentially reveal the dose-dependent alterations of functional connectivity (FC). Thus, present study aimed to investigate alteration of FC in rhesus monkeys at different concentrations of sevoflurane (1.0, 1.3, 1.6 MAC) using resting-state fMRI.

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