Abstract #1842
Bilateral functional connectivity for complex finger movements declines as aging: an fMRI and SEM exploration
Sachiko Kiyama 1 , Mitsunobu Kunimi 1 , Tetsuya Iidaka 2 , and Toshiharu Nakai 1
1
National Center for Geriatrics and
Gerontology, Ohbu, Japan,
2
Nagoya
University, Nagoya, Japan
The present study attempted to seek age related declines
of functional connectivity within the motor cortices,
with particular focus on the effect of movement
complexity. fMRI and SEM (structural equation modeling)
were utilized to compare neural activity between younger
and elderly groups during the visually guided bimanual
finger movement task with easier symmetrical mode and
complex asymmetrical one. Results revealed age-related
differences in functional connectivity within bilateral
PMd and that between bilateral SPL during the task,
suggesting that the elderlyfs inaccuracy of complex
finger movements in tune with visual information derives
from declines in bilateral connectivity within these
regions.
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