Comparison of Quantitative Heterogeneity of Brain Tumors from Diffusion MR Versus Histological Tumour Grade: A Preliminary Study
Dr. Venkatraman Bhat 1 , Lalit Gupta 2 , and Dr. Sundararaman VK 2
Narayana Hrudayalaya Hospital, Bangalore,
India Limited, Bangalore, Karnataka, India
In this study, heterogeneity of brain tumors from
Apparent Diffusion Co-efficient (ADC) maps is compared
with histological tumour grade. 1.5T MR data from 10
patients with brain tumour was retrospectively analyzed.
Based on modified co-occurrence matrix based method, a
heterogeneity index was computed, which was then
compared with the final histological tumour grade after
surgical resection. Heterogeneity index (from ADC maps)
could discriminate between grade 4 and lower grade
tumours. For lower grade tumours, small sample size
precluded comparative analysis between tumour grade and
heterogeneity index. Tumour heterogeneity could be a
better marker for tumour grade than mean ADC values.
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