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Abstract #1862

Functional and anatomical changes of somatosensory cortex in rats recovering from severe neonatal hypoxic-ischemic encephalopathy (HIE) brain injury

Jae-Hun Kim 1 , Geun Ho Im 2 , Won Beom Jung 2 , Moon-Sun Jang 2 , Kyoung-Nam Kim 2 , Julius Juhyun Chung 3 , Sun Young Chae 3 , and Jung Hee Lee 1

1 Radiology, Samsung Medical Center, Seoul, Seoul, Korea, 2 Center for Molecular and Cellular Imaging, Samsung Biomedical Research Institute, Samsung Medical Center, Seoul, Seoul, Korea, 3 Samsung Advanced Institute for Health Sciences & Technology, Sungkyunkwan University, Seoul, Seoul, Korea

We examined the functional and anatomical changes of somatosensry cortex in rats recoverying from severe neonatal hypoxic-ischemic encephalopathy (HIE) brain injury. In BOLD fMRI, the left brain activation was revelaed for the left forepaw stimuatlion in HIE rats with an evidence of functional and anatomical disconnection between left and right hemisphere using resting state fMRI and DTI. But more fiber tracks were observed in frotnal brain in the HIE rats than sham-operated rats. In this study, therefore, we found the inter- and intra-hemispheric brain reorganization to compensate for impaired somatosensory fuctnion in HIE rast at 9 weeks after inducing hypoxic-ischemic brain injury.

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