Asymmetric magnetization transfer effects for perfusion imaging in transient ischemic brain tissue in rats
Kazuhiro Nakamura 1 , Junko Kawamura 1 , Yasushi Kondoh 1 , Hajime Miyata 1 , and Toshibumi Kinoshita 1
Akita Research Institute for Brain and Blood
Vessels, Akita, Akita, Japan
Several studies show post-ischemic hyperperfusion at 48
hours after reperfusion in the transient ischemic tissue
using continuous arterial spin labeling (CASL) method.
Asymmetric magnetization transfer (MT) effects have not
been investigated in these studies. In our experiments,
cerebral blood flow (CBF) using CASL method (CASL CBF)
with minus polarities of the labeling gradient was
higher than that with plus polarities. The results
showing asymmetric MT effect in CASL CBF must be
compensated even though the two-coil system. After
compensation of the MT effect, CASL CBF at 48 hours
after reperfusion was still significantly higher than at
24 and 72 hours.
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