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Abstract #1894

Cognition decline and Cortical thickness change in Chronic Kidney Disease patients

Chun-Yuan Chang 1,2 , Fa-Hsuan Lin 1 , and Jong-Ling Fuh 3

1 Institute of Biomedical Engineering, National Taiwan University, Taipei, Taiwan, Taipei, Taiwan, 2 2Department of Neurology, Min-Sheng General Hospital, Taoyuan, Taiwan, Taoyuan, Taiwan, 3 Neurological Institute, Taipei Veterans General Hospital, Taiwan, Taipei, Taiwan

The CKD patients had smaller total cerebral cortex volume and smaller cortical thickness compared to the control subjects. Moreover,in neurocognition test,the CKD groups showed lower scores in MMSE, MoCA and digit span forward compared with the normal control group significantly.The CKD subjects had smaller gray matter volume compared with the control subjects in some brain regions.

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