Abstract #1914
An investigation of functional connectivity in the cognitive control network in Prodromal Huntington's Disease
Katherine A Koenig 1 , Mark J Lowe 1 , Jian Lin 1 , Deborah L Harrington 2 , Ken E Sakaie 1 , Jane S Paulsen 3 , and Stephen M Rao 4
1
Imaging Sciences, The Cleveland Clinic,
Cleveland, OH, United States,
2
Research,
Neurology, and Radiology Services, Veterans Affairs San
Diego Healthcare System, San Diego, CA, United States,
3
Department
of Psychiatry, The University of Iowa Carver College of
Medicine, Iowa City, Iowa, United States,
4
Neurological
Institute, The Cleveland Clinic, Cleveland, OH, United
States
Activation on a motor task was used to seed a resting
state connectivity analysis in the left primary motor
cortex (M1) in 48 participants in the prodromal stages
of Huntingtons disease (preHD) and 16 gene-negative
participants. Bilateral anterior cerebellar lobes and
bilateral middle temporal gyri showed a relationship
between strength of connectivity to left M1 and
time-to-onset in preHD. These findings suggest that
connectivity strength is impacted by disease process
prior to onset of symptoms in HD.
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