Meeting Banner
Abstract #1920

Comparison of Neuromelanin MRI with FP-CIT SPECT in Parkinson Disease

Paula Trujillo 1,2 , Paul Summers 1 , Giorgio Marotta 3 , Ioannis Isaias 4,5 , and Antonella Costa 1

1 Department of Neuroradiology, Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico, Milan, MI, Italy, 2 Department of Electronics, Information and Bioengineering, Politecnico di Milano, Milan, MI, Italy, 3 Department of Nuclear Medicine, Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico, Milan, MI, Italy, 4 Centro Parkinson, Istituti Clinici di Perfezionamento, Milan, MI, Italy, 5 Neurologische Klinik und Poliklinik, Universittsklinikum Wrzburg, Bayern, Germany

Our aim was to compare contrast-to-noise ratio (CNR) and volume measurements of the substantia nigra (SN) made using NM-MRI with dopamine reuptake in the caudate nucleus and putamen in Parkinsons disease patients as measured using FP-CIT SPECT. Differences in NM-MRI measures between healthy controls (HC) and Parkinsons disease (PD) patients were also examined. Both NM-MRI measures of the SN showed a significant correlation with the FP-CIT binding values, and were significantly different between the HC and PD groups. Our results suggest that NM-MRI may find use in quantifying pathology and following disease progression.

This abstract and the presentation materials are available to members only; a login is required.

Join Here