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Abstract #1922

A Longitudinal Study In Huntingtons Disease Reveals Differential Macro- and Micro-structural Effects

Jessica J Steventon 1,2 , Da Ma 3,4 , Manual J Cardoso 4 , Marc Modat 4 , Mark F Lythgoe 3,4 , Sebastian Ourselin 4 , Rebecca Trueman 2,5 , Anne E Rosser 2 , and Derek K Jones 1

1 Cardiff University Brain Research Imaging Centre (CUBRIC), Cardiff, Wales, United Kingdom, 2 Brain Repair Group, Cardiff University, Cardiff, Wales, United Kingdom, 3 Centre for Advanced Biomedical Imaging (CABI), University College London, London, United Kingdom, 4 Centre for Medical Image Computing (CMIC), University College London, London, United Kingdom, 5 Nottingham University, Nottingham, United Kingdom

Patient studies in Huntingtons Disease (HD) are limited by the incompatibility of MRI with chorea, producing an incomplete picture of neuropathological changes at later disease stages. Here, we used both T2-weighted and diffusion MRI in a mouse model of HD at a pre-symptomatic and symptomatic time-point, where anaesthesia is necessary during scanning but eliminates chorea-related motion artefacts. We apply automated atlas-based segmentation and diffusion tractography for the first time in a knock-in mouse model of HD and find that macro-structural changes preceded micro-structural changes, suggesting microstructural abnormalities may be a downstream effect of grey matter abnormalities in HD.

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